ϲѶѦϼСƽڵоĿٻ2018лҽѧƼɹһȽ

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2019-10-18 Ķ

--ϲѶѦϼСƽڵоɵġӹĤ΢ӻоĿٻ2018лҽѧƼɹһȽ

ѧҽԺ

ҽƴѧҽԺ

Ѧϼ

 

ϺеһӤԺ

Сƽ


ӹĤʳữŷҺҹϺѸ߾Ӹƶλҹ2000-2011ʷһԼ30% δӰŮͽӰͥȶгѧҽԺŶҽƴѧҽԺѦϼŶϺеһӤԺСƽŶоڹȻ֧ϸ֯PٴӹĤ䷢;Ƽ-Ƽغ;֮ļط΢׽ϵͳооɹٴת


ŶȷִƼͨ壨ER/ͼ壩ͬطӻת¼ЧӦƼ壨ERRER干ERĤչҪΪٴERṩۻΪ̽ERĤṩ˼·֮ӹĤڴƼĤ壨mERƼͨmERΪڶʹǻת¼ЧӦӶӹĤƼõġ˫˫ЧӦѧ˵Ϊ׿Ĥṩ


оŶӽол΢ӹĤĹϵǴл쳣ؼȵ/ȵ壨insulin/IRӹĤչҪȵؼȵ壨IRɼPI3K/AKTERKźͨ·ϸȷǴл쳣ĤΪӦҩӹĤṩۻ


֬л쳣֬֯Ϊڷ֬ӴٽӹĤо֬أAcrp30֬أVisfatin ͨյϸͼٽӹĤֳϸϮоΪ֬л쳣Ĥ߸廯ṩ֬ϸԤӹĤ


غ΢ͨϸ򷢻ѧǸоĤطӼΪҪоŶ492ܶȻоƬɸѡص21йȺӹĤDUSP1ΪĤԤ־SHARP1ĤܰͽתƹؼREG P53ͻĤؼΪƺͷӷ͵춨ʵ


оŶӽɹٴתȽл΢оںϲǴл쳣ıӹĤߵ齨ѧŶ(ڷڿڿֳƵȣǴл쳣Ĥм϶˫ȫ70.0%ߵ84.4%32.4%ߵ43.0%ڹˮƽйĸƶоƽ̨ʹĻ֮ӹĤ׽ӹĤܰͽתԤģԤģͣ׼ȷʴ 86%뷢ר2ı˴ͳжԤģʽѧ׼жתƺԤ


оɹƼصͼ顶ӹĤؽ̲


оŶӹǸɶβμŷ޺޸ѧ˹Ӱ


ѧҽԺŶڴ־ɳؽȡԺ족˶չͼֵ˰Ժ֮ҸǻŬȡøɼ


λõԺ˵ҿƸ˼ʮĻҲرлκʦΪӹĤµļʵ˹ͬŬĽ



Ļ֪ͨرעԴڻתس󸾲ҽƴҵߴݸϢٽѧѧϰ֮Ŀζűͬ۵֤ʵݵʵ󸾲ҽתظ漰ȨϵԱǻԸĻɾ֤ȨʹñվϢͷĺκ

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